ERBB1 and ERBB2 Have Distinct Functions in Tumor Cell Invasion and Intravasation
نویسندگان
چکیده
منابع مشابه
ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation.
PURPOSE The epidermal growth factor receptor (ERBB1) and related family member HER-2/neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. Our studies were designed...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2009
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-08-2163